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KMID : 1130620220180030280
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Journal of Clinical Neurology
2022 Volume.18 No. 3 p.280 ~ p.289
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Clinical and Radiological Features of Myelin Oligodendrocyte Glycoprotein-Associated Myelitis in Adults
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Kim Ki-Hoon
Kim Su-Hyun
Hyun Jae-Won
Kim Ho-Jin
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Abstract
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Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have recently been established as a biomarker for MOG-antibody-associated disease (MOGAD), which is a distinct demyelinating disease of the central nervous system. Among the diverse clinical phenotypes of MOGAD, myelitis is the second-most-common presentation in adults, followed by optic neuritis. While some features overlap, there are multiple reports of distinctive clinical and radiological features of MOG-IgG-associated myelitis, which are useful for differentiating MOGAD from both multiple sclerosis and neuromyelitis optica spectrum disorder. In this review we summarize the clinical and radiographic characteristics of MOG-IgG-associated myelitis with a particular focus on adult patients.
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KEYWORD
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myelin oligodendrocyte glycoprotein, demyelinating diseases, myelitis, multiple sclerosis, neuromyelitis optica spectrum disorder
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